GOV — GOVERNMENT

NIH Parent R01 (PA-25-301 / PA-25-305)

National Institutes of Health

Award

Uncapped (>$500K/yr direct needs IC approval), up to 5 years

Deadline

Feb 5, Jun 5, Oct 5 (new); active through Jan 2028

Award type

Cash grant

Focus

Basic science · Preclinical & therapeutics · Clinical research

NIH's standard investigator-initiated mechanism for basic and translational research. Participating institutes include NHLBI, NINDS, NIAMS, NICHD, NIGMS, and NCATS (from the Jul 2026 due dates). Two variants: Clinical Trial Not Allowed (PA-25-301) and Clinical Trial Required (PA-25-305).

Why it's in this index

TAFAZZIN biology, cardiolipin remodeling, and cardiomyopathy, neutropenia, or myopathy mechanisms all fit the parent R01. NHLBI is the natural home for cardiac work and NIAMS for skeletal muscle; the institute you name shapes the review panel.

Who can apply

Academic institutions, nonprofits, for-profits, and governments; foreign organizations eligible (foreign subawards prohibited under the current announcement). Any career stage with a PI-eligible appointment.

How to apply

Electronic submission via eRA Commons / Grants.gov / ASSIST with your institution's grants office. Standard due dates Feb 5, Jun 5, Oct 5; renewals/resubmissions Mar 5, Jul 5, Nov 5.

Links & downloads

PA-25-301 (no clinical trial) ↗PA-25-305 (clinical trial required) ↗